Spintronics are a class of electronics that utilize the intrinsic spin of electrons rather than the flow of charge through a circuit. As a result, they are more energy efficient and faster than conventional electronics and are critical in advancing quantum computing, information sciences, and wearable technologies. Current spintronic designs are composed of heterostructures of stacked thin films of ferromagnetic materials in combination with either antiferromagnetic or nonmagnetic materials.

Plastic plays an important role in modern life, but it also brings sustainability challenges due to its persistence in the environment and the lack of green end-of-life options. Researchers have been actively working on new strategies to mitigate these concerns and produce sustainable alternatives for specifically single-use applications. Cellulose acetate, a cellulose-derived monomer, has emerged as a promising alternative. It offers tunable properties through its degree of substitution, allowing a balance between durability and biodegradability.

Techniques for the detection of extremely high mass ions or the analysis of heterogenous samples in mass spectrometry are often limited by overlapping charge states and poor resolution.¹ The invention of electrospray ionization allowed for ionization of increasingly larger ions in mass spectrometry where multiple charging allows for the mass-to-charge ratio to be much lower than the molecular mass.² In traditional mass spectrometry, the mass-to-charge ratio is measured and then the charge of the ion is deduced from the spacing of isotope pe

Food packaging materials extensively utilize PFAS compounds for their exceptional grease and moisture resistance properties, yet their environmental persistence and potential health implications necessitate robust analytical methodologies.¹ The primary analytical challenges arise from PFAS structural diversity, ultra-trace concentrations, and complex matrix interference from packaging substrates.

Azulene, a 10-π-electron aromatic molecule, is widely used as a test system due to its bright S₂ singlet state, exhibiting anti-Kasha behavior. Despite extensive studies, its gas-phase time dynamics remain controversial. We revisited Azulene in a jet-cooled molecular beam to address these dynamics with a newly developed Ultrafast Resonance-Enhanced Multiphoton Ionization (REMPI) system. In addition, we obtained the first gas-phase REMPI spectrum of the Azulene dimer.

Neuronal calcium sensors (NCS), including neuronal calcium sensor 1 (NCS1) and downstream regulatory element antagonist modulator (DREAM), constitute a family of calcium-binding proteins involved in a wide range of physiological and pathological processes. These include neuronal development, exocytosis, learning and memory, pain perception, and the progression of disorders such as Alzheimer’s and Parkinson’s diseases, autism, and cancer.

De novo protein design has experienced a renaissance in recent years due to advances in generative diffusion-based approaches to develop high affinity, target-specific binders. However, the ability of these tools to generate “new-to-nature” proteins with unique backbones and amino acid sequences that target lipid/protein assemblies has not yet been explored. Here, we apply an end-to-end design pipeline using RFdiffusionAA, LigandMPNN, Chai-1, and Rosetta to develop lipid antigen/CD1-restricted T cell receptor (TCR) mimics.

Total synthesis remains a relevant cornerstone topic of organic chemistry, serving as a ground for new synthetic strategies and methods to access complex natural products that inspire biological discovery. Beyond the construction of complex molecules, modern total synthesis embodies a philosophy of ideality, popularized by Phil Baran, which is the pursuit of routes that are concise, efficient, and impactful, minimizing unnecessary steps while maximizing construction and creativity.

The critical role that carbohydrates and their conjugates play in biological interactions is of interest in medicinal research, making the chemical synthesis of these molecules essential.¹ The complexity of carbohydrates, due to their configuration, connectivity, and composition, makes the chemical synthesis lengthy and complicated.¹ All these factors make synthesizing the stereoselective oligosaccharide a significant challenge. 

The formation of carbon-carbon bonds is a long-standing challenge in synthetic organic chemistry primarily addressed in recent decades via cross-couplings. Cross-coupling has grown to be a powerful tool in organic synthesis in both research and industrial settings, winning the Nobel Prize in 2010. Traditional cross-couplings are primarily held back by the sensitivity of their reagents, and their limitations in forming saturated carbon-carbon bonds. To address these, researchers often look to the field of radical couplings.