Water-soluble synthetic polymers (WSPs), including polyacrylamide, polyvinyl alcohol, and polyethylene glycol, are widely used in consumer and industrial applications such as detergents, cosmetics, and textile processing. Global demand for WSPs is increasing by over 5.4% annually and is expected to reach 12.8 million metric tons within the next decade. After their use, millions of tons of WSPs dissolve and enter environmental systems each year; however, their environmental fate and potential long-term impacts remain poorly understood.