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Synthesis of Erythropoietin

Since approval by the FDA in 1989, erythropoietin (EPO) has been used extensively for the treatment of anemia – especially in those with chronic kidney disease, undergoing chemotherapy, or have acquired immune deficiency syndrome (AIDS).1 EPO is a highly glycosylated glycoprotein containing three N-linked and one O-linked glycosylation sites.

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Synthesis and Application of Functional Nanoparticles for Precision Drug Delivery

Nanoparticles (NPs) are particles of approximately 1-100 nm in size and have properties not found in bulk samples of the same material. Different materials, such as polymers, metal oxides, silica, noble metals, and carbon, can be used to create nanoparticles, which can then carry a variety of bioactive substances for use in biomedical applications, such as proteins, nucleic acids, small molecules for chemotherapy, and diagnostics.

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Cellulose Nanocrystals: Preparation, Modification and Applications

Over the past years nanocellulose has proven to be one of the most prominent green materials of modern times. Nanocellulose is derived from the most abundant natural polymer, cellulose, from various physical and chemical processes. Even though cellulose has been widely utilized for several decades, nanocellulose has emerged as a prominent material in the last two decades. Nanocellulose can be mainly divide into three types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial cellulose (BC), having a size about 100nm.

Quantification of Per- and Polyfluoroalkyl Substances from PM2.5 using LC-MS

Particulate matter (PM) is a mixture of solid or liquid particles suspended in a gas. Fine particles with diameters smaller than 2.5 mm (PM2.5) present a large human health concern because they can penetrate lower into the respiratory tract causing cardiovascular and respiratory diseases and lung cancer. A group of organic compounds previously observed in PM2.5, per- and polyfluoroalkyl substances (PFAS), are present in a variety of environments.

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Measuring Isotope Incorporation in Proteins Produced Using Uniform or Sparse Labeling with 13C and 15N

Sparse labeling is a strategy for isotopic enrichment in proteins grown in mammalian systems, such as glycoproteins. We have developed a customized isotope simulator that can simulate enriched peptide and protein isotope patterns. Using this simulator, we have developed a software to experimentally determine the abundance of 13C and 15N in enriched peptides and proteins using isotope patterns and mass information from conventional mass spectrometers.

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Characterization and Thermal Decomposition of Sub-allotrope Violet Phosphorus-21

Phosphorus, one of many elements that fall under the umbrella of inorganic chemistry, is currently experiencing a renaissance due to advancements in synthetic methodology. Currently, there are 4 primary allotropes of phosphorus. While red, white, and black phosphorus have been well-studied, it is only recently that a reliable synthesis of crystalline violet phosphorus has been established.

Mechanistic Underpinnings of Phototoxicity and Photobluing: Using Organic Photochemistry and DFT to Help Solve Problems in Photomedicine and Photobiology

My research group is interested in mechanistic insights to sort out the reactive oxygen intermediates in photooxidation reactions. We have made contributions to the fields of photooxidation and oxygen-transfer processes, including singlet-oxygen disinfection priming and selective oxidations. In this seminar, one topic to be discussed is the shrinking of a molecular gap (so-to-speak), that is improving of mechanistic understanding of a phototruncation through physical organic chemistry.

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