Fluorine has quickly become an atom of great importance in pharmaceutical development. Fluorine, being the element with the highest electronegativity,  can impart substantial changes to a molecule’s chemical and physical properties. Incorporation of fluorine into a given framework can be divided into both nucleophilic and electrophilic fluorinating reagents. Particularly, nucleophilic fluorination has the distinct advantage over electrophilic fluorination when accessing radioactive [¹⁸F] labeled substances.

Nucleophilic dearomatization receives attention for its ability to install stereogenicity within a molecule using few steps. Whilst using aromatic substrates as a starting material can be difficult due to the low reactivity, methods have been developed to utilized them as building blocks. Exploring into pharmaceuticals and natural products will show a common moiety in di/tetrahydro pyridine and piperidines. These moieties can be synthesized via nucleophilic dearomatization of pyridines.

Diels–Alder (DA) reactions featuring furan as diene have often been plagued with a variety of challenges due to the ease of reversibility.^[1] Factors that contribute to this trend stem from a large HOMO–LUMO gap between furan and the dienophile as well as the greater ring-strain of the newly furnished oxa-norbornene cycloadduct in contrast to cyclopentadiene, its carbo-congener. To address these shortcomings, highly activated furans and/or dienophiles have been developed to achieve the desired cycloaddition.

Daidzein, a bioactive isoflavonoid found in soybeans, roselle, and other legumes, has gained attention for its antioxidant, anti-inflammatory, and estrogenic properties.¹ Its therapeutic potential in bone health, cardiovascular protection, and cancer prevention has positioned it as a key compound in nutraceuticals and functional foods.^1,2  Accurate extraction and analysis of daidzein are critical for quality control, pharmacokinetics studies, and broader applications in the growing market for plant-based bioactives.^2,3 &nbsp

Late-stage functionalization, a transformative strategy in medicinal chemistry, enables precise modification of molecular frameworks through atom insertion, deletion, or exchange, offering rapid access to novel pharmacophores and enhancing drug discovery efforts.

Criegee intermediates, formed from the ozonolysis of alkenes, are known to have a role in atmospheric chemistry, including the modulation of the oxidizing capacity of the troposphere. Although studies have been conducted since their discovery, the synthesis of these species in the laboratory has ushered in a new wave of investigations of these structures, both theoretically and experimentally.