Application of PNIPAM-Based Microstructured Surfaces for Label-Free Cell Sorting

Cell sorting enables the separation of specific cell types from heterogeneous populations and is widely used in biomedical research, drug development, and regenerative medicine. Existing methods fall into two categories: label-based techniques, such as fluorescence-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS), which rely on antibodies conjugated to fluorescent dyes or magnetic beads; and label-free techniques, which exploit intrinsic physical properties such as size, deformability, or electrical charge.

Type of Event:
Materials Chemistry and Nanoscience Seminar

Adsorption Phenomena of VOCs in Thin Films of Rigid and Flexible Metal-Organic Frameworks

In this talk I will introduce vapor-assisted synthesis as a versatile technique to deposit metal-organic framework (MOF) thin films on solid substrates. Despite the large number of publications in the MOF community, only a small fraction of these publications focus on thin film synthesis. For certain applications, such as chemical sensors, thin films are necessary to reduce the response time and increase the analytical sensitivity of a transducer.

Type of Event:
Physical Seminar

Deriving Three One Dimensional NMR Spectra from a Single Experiment Through Machine Learning

NMR-based metabolomics is a robust analytical tool used to investigate the chemical phenotype of biofluids. The relationships between its components and human health has the potential to alter clinical practices, including treatment efficacy and disease prognosis. As an intrinsically quantitative, highly reproducible and non-destructive technique, often requiring little sample preparation, NMR is ideal for metabolomics.

Type of Event:
Analytical Seminar

Targeted Degradation of Indoleamine 2,3-Dioxygenase 1 Using PROTAC Technology

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that catalyzes the first and 
rate-limiting step in the oxidative metabolism of tryptophan along the kynurenine pathway. 
Aberrant activation of this pathway is strongly associated with tumor immune suppression. 
Overexpression of IDO1 in tumor cells and antigen-presenting cells results in local depletion of 
tryptophan and accumulation of immunomodulatory metabolites such as kynurenine. These 

Type of Event:
Organic Seminar

Chemistry and Spectroscopy of
the HNCO+ and HNCS+ Ions -
Potential Precursors for Interstellar HNCO and HNCS

Isocyanic acid (HNCO) and isothiocyanic acid (HNCS), both relevant to prebiotic chemistry, have been detected in the interstellar medium, yet the formation pathways of these species remain largely unverified experimentally. Proposed mechanisms involve their cationic precursors (HNCO⁺, HNCS⁺) and hydrogen-loss products (NCO⁺, NCS⁺), none of which have been observed astronomically due to the lack of vibrational and rotational reference data.
 
Type of Event:
Physical Seminar

Hansen Solubility Parameters as a Predictive Tool for Formulating Amorphous Solid Dispersions

 A major challenge in pharmaceutical development is the poor aqueous solubility of majority of the crystalline active pharmaceutical ingredients (APIs) generated in drug discovery.  Amorphous solid dispersions (ASDs) improve solubility by molecularly dispersing amorphous APIs within a glassy polymer matrix; however, their utility is often constrained by limited drug loading capacity and incomplete drug dissolution.

Type of Event:
Materials Chemistry and Nanoscience Seminar
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