Tags: Organic Seminar

Over the past century, one of the most enduring challenges in drug discovery has been the large proportion of the human proteome considered “undruggable.” The key reasons are twofold: most protein surfaces are relatively flat, and many proteins are unstructured and highly flexible. As a result, over 85% of human proteins remain inaccessible to traditional small-molecule inhibitors. Furthermore, conventional inhibitors are typically reversible,…
Asymmetric C–H functionalization offers a direct and efficient approach for constructing chiral C–C and C–X bonds, streamlining access to complex molecules. Traditionally, this transformation relies on transition metal catalysis using noble metals such as iridium and rhodium, however their scarcity and high cost limit widespread application. To address these challenges, the Cramer group explored cobalt(III) as a more abundant alternative,…