Diazo compounds were first discovered by Peter Griess in 1858.¹ The diazo group has been widely used due to its diverse reactivity, including alkylation, carbene generation, nucleophilic addition, homologation, and ring expansion. 

Since approval by the FDA in 1989, erythropoietin (EPO) has been used extensively for the treatment of anemia – especially in those with chronic kidney disease, undergoing chemotherapy, or have acquired immune deficiency syndrome (AIDS).¹ EPO is a highly glycosylated glycoprotein containing three N-linked and one O-linked glycosylation sites.

Nanoparticles (NPs) are particles of approximately 1-100 nm in size and have properties not found in bulk samples of the same material. Different materials, such as polymers, metal oxides, silica, noble metals, and carbon, can be used to create nanoparticles, which can then carry a variety of bioactive substances for use in biomedical applications, such as proteins, nucleic acids, small molecules for chemotherapy, and diagnostics.

¹ Institute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany; e-mail: prs@uni-giessen.de; www.uni-giessen.de/schreiner 

Keywords: catalysis • chemical bonding • noncovalent interactions 

Professor Gregory Robinson, UGA Foundation Distinguished Professor of Chemistry in the Franklin College of Arts and Science, was awarded the 2023 faculty Blue Key Service Award at the university’s annual Tucker Dorsey Blue Key Alumni Banquet on Nov. 10 at the University of Georgia Center for Continuing Education & Hotel.

Professor David Crich, Eminent Scholar and Professor of Chemistry and Pharmaceutical and Biomedical Sciences, is among five University of Georgia researchers selected by the National Academy of Inventors (NAI) as 2024 NAI Senior Members, the largest single induction for the university in its history. 

Over the past years nanocellulose has proven to be one of the most prominent green materials of modern times. Nanocellulose is derived from the most abundant natural polymer, cellulose, from various physical and chemical processes. Even though cellulose has been widely utilized for several decades, nanocellulose has emerged as a prominent material in the last two decades. Nanocellulose can be mainly divide into three types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial cellulose (BC), having a size about 100nm.

Particulate matter (PM) is a mixture of solid or liquid particles suspended in a gas. Fine particles with diameters smaller than 2.5 mm (PM_2.5) present a large human health concern because they can penetrate lower into the respiratory tract causing cardiovascular and respiratory diseases and lung cancer. A group of organic compounds previously observed in PM_2.5, per- and polyfluoroalkyl substances (PFAS), are present in a variety of environments.

Sparse labeling is a strategy for isotopic enrichment in proteins grown in mammalian systems, such as glycoproteins. We have developed a customized isotope simulator that can simulate enriched peptide and protein isotope patterns. Using this simulator, we have developed a software to experimentally determine the abundance of ¹³C and ¹⁵N in enriched peptides and proteins using isotope patterns and mass information from conventional mass spectrometers.