Adaptations of Cells and Tissues to Spatiotemporally Dynamic Mechanical Environments

In recent years significant progress has been made towards understanding the molecular and cellular mechanism by which cells “feel” their environment. There exists a complex relationship between the behavior of a cell, its physical properties, and its surrounding environment.

Prof. Amanda Frossard Receives NSF CAREER Award

Amanda Frossard, Assistant Professor in the Department of Chemistry, was awarded an CAREER award from the National Science Foundation (NSF). This is the most prestigious award given by NSF to early career faculty. This award includes five years of funding to support Dr. Frossard’s research and teaching in the field of atmospheric chemistry. Her work will focus on understanding the chemical and physical properties of surfactants in atmospheric aerosol particles and measuring the influence of surfactants on aerosol particle hygroscopic growth.

Chemical and Physical Properties of Surfactants in Seawater and Aerosol Particles and Their Influence on Particle Hygroscopic Growth

The size and composition of atmospheric aerosol particles modulate their interactions with solar radiation, and thus their influence on climate and visibility. The radiative effects of aerosol particles remain a large uncertainty in accurately modeling and predicting current and future climates. Recent work has demonstrated the presence of organic surfactant molecules in atmospheric aerosol particles, and their sources and transformations in the atmosphere are currently being studied.

Characterization of Extracellular Vesicles Derived from Red Blood Cells Using Vibrational Spectroscopy and Imaging

Richard A. Dluhy,Amareshwari Konutham1, Shaiju S Nazeer1
Joo-Yeun Oh2, Amit Gaggar2, and Rakesh P. Patel2

1Department of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294
2Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294

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From Molecular Gyroscopes to Homeomorphic Isomerization: Molecules that Turn Themselves Inside-Out

Children never cease to be fascinated by toy gyroscopes, which commonly consist of (1) a rotating axis and disk, and (2) two to four spokes that connect the termini of the axis. This talk will describe syntheses of molecules that duplicate the connectivity, symmetry, and rotational ability of such gyroscopes. Complexes with trans R3P-MLn -PR3 linkages are first prepared, with R groups that terminate with a CH=CH2 moiety. Then alkene metathesis followed by hydrogenation is used to construct three-spoked cage molecules.