The increasing incidence of antibiotic resistance underscores the pressing need for studies aimed at understanding its underlying mechanisms. Bacterial membrane lipids provide an avenue for studies, as they are crucial for maintaining the integrity and functionality of bacterial cell membranes. However, in-depth studies on the involvement of bacterial membrane lipids require working with numerous bacterial samples, which necessitates the need for a high-throughput lipid extraction method.

Intrinsically disordered proteins (IDPs) - polypeptides that lack a defined three-dimensional structure – are commonplace in eukaryotic proteomes and often have critical impact on correct functioning of biological processes. IDPs can mediate low affinity interactions between proteins and serve as a scaffold or intermediate binding agent.

Surgical resection remains a primary treatment for solid tumors. However, achieving tumor-free margins during surgery is challenging. Residual cancer cells at surgical margins are associated with increased recurrence and reduced survival rates. Intraoperative evaluation of surgical margins could enable more complete resection and reduce positive margins. Traditional frozen section histopathology has limitations including time-consumption, sampling errors, and availability of expertise.

Thioglycosides and thiasugars both have a long history in bioorganic and medicinal chemistry ^1-7 but it is widely considered that they are less “active” than the parent sugars.

Peptide cyclization methods are useful in the development of therapeutic peptide leads with improved metabolic stability properties. To develop residue-selective peptide cyclization strategies, we draw inspiration from cyclic and lassoed peptide natural product scaffolds that exhibit diverse biological activities.

The Department of Chemistry will host an Open House on Thursday, August 24, from 2:30-4:00 p.m. in the breezeway between the iSTEM-1 and iSTEM-2 buildings. If you've ever considered majoring in Chemistry or adding it as a minor, or are simply curious about what UGA Chemistry has to offer, this is the event for you! 

Offerings at the Open House include:

The high prevalence of aromatics in natural products and potential drug candidates makes them intriguing candidates for continued development of C-H functionalization reactions that proceed with high positional selectivity. Achieving site-selectivity can be a steep challenge as when there is a lack of appropriate directing groups or substitution patterns, more than one product isomer is commonly produced. Therefore, the development of aromatic C-H functionalization by means of chemo and site-selective activation is of interest. 

The presence of a heteroatom-heteroatom bond is a “structural alert” in medicinal chemistry, of which the hydroxylamine N-O bond, with its bond dissociation energy of 55-65 kcal·mol^-1 and reputation for inherent mutagenicity and genotoxicity, is a pertinent example.^1-3  Due to this broad moratorium, hydroxylamines are overwhelmingly excluded in medicinal chemistry optimization schemes and have thus received little attention from the synthetic chemistry or drug discovery communities.