Exploration of the Bacterial Lipidome using Hydrophilic Interaction Chromatography and Ion Mobility-Mass Spectrometry

The bacterial lipidome has recently gained appreciation as an important factor in antibiotic resistance and host-pathogen interactions during infection. However, the study of bacterial lipids can be particularly challenging due to the presence of lipid species that are unique to bacteria in general, as well as several lipid classes that are unique to individual species of bacteria.

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Multi electrode harmonized Kingdon traps as mass analyzers for FT based mass spectrometers

Kingdon trap [1] is the simplest ion trap consisting of wire and cylindrical electrode surrounding with different potential.  Well-known Orbitrap [2], has emerged as development of R. D. Knight’s idea [3], who modified the cylinder electrodes geometry to make the field inside Kingdon trap quadratic (harmonic) and proposed measuring the frequencies of ions oscillating in such field by resonant excitation of their motion along trap axis, to determine their masses [3].

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