Chemical measurement science does not respect divisional boundaries and often integrates aspects from the domain of chemistry.  Therefore, one may arrive at a point similar to the legendary musician, Gram Parsons, who coined his art cosmic country as it represented something more than the core genre.  Here, I begin to fully embrace the broader aspects of mass spectrometry based measurements.  Mass is a defining physical parameter and is fundamentally constrained by the rules of chemical bonding.  When measurements are made with sufficiently high mass resolving power, direct insights into the elemental composition of an ionized molecule can be provided by the instrumental platform.  In this context,  ongoing efforts in the lab have focused on the provision of this capability for mass spectrometry imaging (MSI) where the convergence of variable ion populations and extended measurement times generate a unique problem space.  Developments have been made that span animal and plant model systems and environmental exposures to further elevate the measurement performance of Fourier transform mass spectrometry (FTMS).  Additional developments for tandem mass spectrometry that complement this work will be briefly highlighted. These addressed instrumental demands also exist within the broader scope of complex mixture analysis.  Moving forward, these approaches will be increasingly applied to measurement of complex environmental mixtures from aquatic and terrestrial ecosystems that will inform broader relationships between molecular-level attributes and ecological observables.