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Hydrogen and Halogen Bonding: Application, Competition, and Control

Bryan Soto
Bryan Soto
Department of Chemistry
University of Georgia
Chemistry Building, Room 400
Organic Seminar

Hydrogen bonding is one of the most well-characterized non-covalent interactions.  Analogous to hydrogen bonding, halogen bonding has become an important focus of study, notably in supramolecular chemistry.  The geometric specificity of hydrogen and halogen bonding is often exploited to build crystal frameworks.  These two interactions can be used in tandem to created novel organic frameworks.  Direct competition occurs between the interactions as the same acceptors can form both interactions.  Understanding this competition has lead to an increase in research on how to control these interactions and drive crystal formation. 

Key References:

  1. Aakeroy, C. B., Spartz, C. L., Dembowski, S., Dwyre, S., and Desper, J., IUCrJ, 2015, 2, 498-510
  2. Riel, A. M. S., Decato, D., Sun, J., Massena, C. J., Jessop, M. J., Berryman, O. B., Chem. Sci., 2018, 9, 5828
  3. Robertson, C. C., Wright, J. S., Carrington, E. J., Perutz, R. N., Hunter, C. A., Brammer, L. Chem. Sci., 2017, 8, 5392 -5398
  4. Cavallo, G., Metrangolo, P., Milani, R., Pilati,, T., Priimagi, A,. Resnati, G., Terraneo, G., Chem. Rev., 2016, 116, 2478-2601

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