Tags: Analytical Seminar


Characterization of Hydrophilic Post Translational Modifications by LC-MS

Post Translational Modifications (PTM) are modifications which take place following protein biosynthesis. There are hundreds of PTMs which have been discovered and possibly many more which have yet to be discovered. The analysis of the 20 amino acids to study has exponentially increased to seemingly limitless combinations of proteins and PTMs, and this number of possible PTM combinations add daunting challenges for proteomic analysis. The most…


Interaction between heparan sulfate and the Roundabout receptor at the single-molecule level

Scanning probe microscopy methodologies have advanced to the point that in situ measurements of complex biological systems can be routinely measured at the single-molecule level1, providing information on rare states that can be lost in standard ensemble measurements2and allowing highly specific detection of various proteins and polysaccharides3,4. One such system that has attracted considerable attention is that of the cell signaling pathway…


Chemical exchange and saturation transfer (CEST) based magnetic resonance imaging (MRI)


Nanoparticle Synthesis using Shock Tubes


Analysis of Water and Soil Samples using Portable Instruments

The Environmental Protective Agency (EPA) monitors and regulates harmful chemical contaminants in the environment in order to reduce the detrimental effects they have on people and the environment. In order to monitor these contaminants, specifically in water and/or soil, people are required to go to the location of interest and collect samples to bring back to a laboratory to be analyzed. This process requires samples to be stored and preserved…


Iodine Based Nanotherapeutics


Particle Surface Modification for Improved Properties and Applications

Advancing requirements for composites having enhanced chemical, mechanical and physical properties are being met by molecular modifications of  both  filler particles and the matrix they are placed in. The presenter has enjoyed making successful contributions to a wide variety of technical problems by employing various chemical principles for particle synthesis and surface modification. Both synthetic and physical chemical deposition…


Bio-Responsive Polyrotaxane-Based Nanochelators for Improving Transfusional Iron Chelation Therapy

Iron overload (IO) is one of the most common genetic diseases in the U.S. but individuals with the condition typically exhibit few symptoms in the early stages and are often unaware of their condition until it has already progressed to a dangerous level. Untreated, IO can induce cirrhosis and increase risk of liver cancer, cause arthritis, or lead to impotence. Recent studies have furthermore consistently demonstrated the presence of excess iron…


Hair Reveals what People Conceal: Biometric Traits from the Chemical Analysis of Human Hair

This presentation reveals the profound ways in which isotope ratio mass spectrometry (IRMS) can provide information about the geographic origin and history of almost everything around us, including our fellow humans. The presentation explains the ways in which we are and are not exactly what we eat, and it explains how researchers use IRMS measurements of hair to determine the geographic origin and travel histories of animals and humans.…


A methodological perspective on the reactivity of organic carbon in the sea

The oceans contain the largest proportion of carbon atoms that participate in biogeochemical cycles on Earth's surface over timescales ranging from less than a second to thousands of years.  Radiocarbon (14C) measurements suggests that most (~95 %) of the carbon atoms bound within organic molecules in seawater can persists for thousands of years.  The abundances of these atoms at each time and place in the ocean are complete records of…
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