Timothy Dore’s scientific interests lie at the interface of chemistry and biology, creating new technology to study complex biological systems, especially the brain. After graduate work in synthetic organic chemistry in Paul Wender's laboratory at Stanford University, he completed postdoctoral training in Roger Tsien's laboratory at the Howard Hughes Medical Institute and the University of California, San Diego. He began his independent career at the University of Georgia in 2000, and moved to New York University Abu Dhabi in 2012. Dr. Dore has been an adjunct faculty member at UGA since 2012.
- BSCHEM, University of North Carolina
- PhD, Stanford University
To increase our understanding of biology and medicine, the scientific community requires the continued development of new technologies for studying and manipulating cell physiology. The research interests of the Dore Laboratory at NYUAD lie at the interface of chemistry and biology, creating new technology to study complex biological systems. The power to design and synthesize molecules with appropriate function coupled with an understanding of reaction mechanisms enables the work. The research is multidisciplinary in nature, involving organic chemistry, biochemistry, photochemistry, microscopy, and molecular and cell biology. The complexity of the problems addressed necessitates collaborations with other scientists around the world. Current projects focus on three major areas:
- Light-driven tools to study biological systems
- CaaX proteases and the role they play in regulating cell physiology
- Discovering inhibitors of sodium-glucose cotransporters SGLT1 and SGLT2
Asad, N.; Deodato, D.; Lan, X.; Widegren, M. B.; Phillips, D. L.; Du, L.; Dore, T. M. Photochemical Activation of Tertiary Amines for Applications in Studying Cell Physiology. J. Am. Chem. Soc. 2017, 139, 12591-12600.
Huang, J.; Muliawan, A. P.; Ma, J.; Li, M. D.; Chiu, H. K.; Lan, X.; Deodato, D.; Phillips, D. L.; Dore, T. M. A spectroscopic study of the excited state proton transfer processes of (8-bromo- 7-hydroxyquinolin-2-yl)methyl-protected phenol in aqueous solutions. Photochem. Photobiol. Sci. 2017, 16, 575-584.
Jesus, A. R.; Vila-Viçosa, D.; Machuqueiro, M.; Marques, A. P.; Dore, T. M.; Rauter, A. P. Targeting Type 2 Diabetes with C-Glucosyl Dihydrochalcones as Selective Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: Synthesis and Biological Evaluation. J. Med. Chem. 2017, 60, 568-579.
Mohammed, I.; Hampton, S. E.; Ashall, L.; Hildebrandt, E. R.; Kutlik, R. A.; Manandhar, S. P.; Floyd, B. J.; Smith, H. E.; Dozier, J. K.; Distefano, M. D.; Schmidt, W. K.; Dore, T. M. 8-Hydroxyquinoline-Based Inhibitors of the Rce1 Protease Disrupt Ras Membrane Localization in Human Cells. Bioorg. Med. Chem. 2016, 24, 160-178.
Rea, A. C.; Vandenberg, L. N.; Ball, R. E.; Snouffer, A. A.; Hudson, A.; Zhu, Y.; McLain, D. E.; Johnston, L. L.; Lauderdale, J. D.; Levin, M.; Dore, T. M. Light Activated Serotonin for Exploring Its Action in Biological Systems. Chem. Biol. 2013, 20, 1536-1546.