Current Research

Our research focuses on the development and evaluation of metal-, polymer- or protein-based nanoparticles for imaging and therapy. The idea is to conceptualize the nanoparticles not as merely tiny aggregates of molecules but rather as platforms with large surface-to-volume ratios. By harnessing the well-developed surface chemistry, one can load a wide range of functionalities onto the particle surface. We adopt an interdisciplinary approach, taking advantage of the recent progress on peptide/protein/materials chemistry, bioconjugation, molecule imaging, cell/molecular biology as well as clinical medicine, and integrating these merits, with rational design, into smart nanoscale gadgets. 

Research website: http://xie.uga.edu/index.html

Selected Publications

Chen, H. ; Wang, G. D. ; Chuang, Y. - J. ; Zhen, Z. ; Chen, X. ; Biddinger, P. ; Hao, Z. ; Liu, F. ; Shen, B. ; Pan, Z. ; Xie, J. Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment. Nano Lett 2015.
Zhen, Z. ; Tang, W. ; Chuang, Y. - J. ; Todd, T. ; Zhang, W. ; Lin, X. ; Niu, G. ; Liu, G. ; Wang, L. ; Pan, Z. ; Chen, X. ; Xie, J. Tumor vasculature targeted photodynamic therapy for enhanced delivery of nanoparticles. ACS Nano 2014, 8, 6004-13.
Chen, H. ; Wang, G. D. ; Tang, W. ; Todd, T. ; Zhen, Z. ; Tsang, C. ; Hekmatyar, K. ; Cowger, T. ; Hubbard, R. B. ; Zhang, W. ; Stickney, J. ; Shen, B. ; Xie, J. Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging. Adv Mater 2014, 26, 6761-6.
Todd, T. ; Zhen, Z. ; Tang, W. ; Chen, H. ; Wang, G. ; Chuang, Y. - J. ; Deaton, K. ; Pan, Z. ; Xie, J. Iron oxide nanoparticle encapsulated diatoms for magnetic delivery of small molecules to tumors. Nanoscale 2014, 6, 2073-6.
Tang, W. ; Zhen, Z. ; Yang, C. ; Wang, L. ; Cowger, T. ; Chen, H. ; Todd, T. ; Hekmatyar, K. ; Zhao, Q. ; Hou, Y. ; Xie, J. Fe5C2 nanoparticles with high MRI contrast enhancement for tumor imaging. Small 2014, 10, 1245-9.
Chen, H. ; Zhen, Z. ; Todd, T. ; Chu, P. K. ; Xie, J. Nanoparticles for Improving Cancer Diagnosis. Mater Sci Eng R Rep 2013, 74, 35-69.
Chen, H. ; Zhen, Z. ; Tang, W. ; Todd, T. ; Chuang, Y. - J. ; Wang, L. ; Pan, Z. ; Xie, J. Label-free luminescent mesoporous silica nanoparticles for imaging and drug delivery. Theranostics 2013, 3, 650-7.
Zhen, Z. ; Tang, W. ; Chen, H. ; Lin, X. ; Todd, T. ; Wang, G. ; Cowger, T. ; Chen, X. ; Xie, J. RGD-modified apoferritin nanoparticles for efficient drug delivery to tumors. ACS Nano 2013, 7, 4830-7.
Zhen, Z. ; Tang, W. ; Guo, C. ; Chen, H. ; Lin, X. ; Liu, G. ; Fei, B. ; Chen, X. ; Xu, B. ; Xie, J. Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer. ACS Nano 2013, 7, 6988-96.
Liu, G. ; Choi, K. Y. ; Bhirde, A. ; Swierczewska, M. ; Yin, J. ; Lee, S. W. ; Park, J. H. ; Hong, J. I. ; Xie, J. ; Niu, G. ; Kiesewetter, D. O. ; Lee, S. ; Chen, X. Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate. Angewandte Chemie International Edition 2011, 51, 445 - 449.
Xie, J. ; Liu, G. ; Eden, H. S. ; Ai, H. ; Chen, X. Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. Accounts of chemical research 2011, 44, 883-92.
Zhu, L. ; Xie, J. ; Swierczewska, M. ; Zhang, F. ; Lin, X. ; Fang, X. ; Niu, G. ; Lee, S. ; Chen, X. Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions. Bioconjugate chemistry 2011, 22, 1001-5.
Lin, X. ; Xie, J. ; Niu, G. ; Zhang, F. ; Gao, H. ; Yang, M. ; Quan, Q. ; Aronova, M. A. ; Zhang, G. ; Lee, S. ; Leapman, R. ; Chen, X. Chimeric ferritin nanocages for multiple function loading and multimodal imaging. Nano letters 2011, 11, 814-9.
Lin, X. ; Xie, J. ; Zhu, L. ; Lee, S. ; Niu, G. ; Ma, Y. ; Kim, K. ; Chen, X. Hybrid ferritin nanoparticles as activatable probes for tumor imaging. Angewandte Chemie (International ed. in English) 2011, 50, 1569-72.
Xie, J. ; Zhang, F. ; Aronova, M. ; Zhu, L. ; Lin, X. ; Quan, Q. ; Liu, G. ; Zhang, G. ; Choi, K. - Y. ; Kim, K. ; Sun, X. ; Lee, S. ; Sun, S. ; Leapman, R. ; Chen, X. Manipulating the Power of an Additional Phase: A Flower-like Au-Fe(3)O(4) Optical Nanosensor for Imaging Protease Expressions In vivo. ACS nano 2011.
Xie, J. ; Chen, K. ; Huang, J. ; Lee, S. ; Wang, J. ; Gao, J. ; Li, X. ; Chen, X. PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 2010, 31, 3016-22.
Lee, S. ; Xie, J. ; Chen, X. Peptides and peptide hormones for molecular imaging and disease diagnosis. Chemical reviews 2010, 110, 3087-111.
Xie, J. ; Lee, S. ; Chen, X. Nanoparticle-based theranostic agents. Advanced drug delivery reviews 2010, 62, 1064-79.
Huang, J. ; Bu, L. ; Xie, J. ; Chen, K. ; Cheng, Z. ; Li, X. ; Chen, X. Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles. ACS nano 2010, 4, 7151-60.
Niu, G. ; Li, Z. ; Xie, J. ; Le, Q. - T. ; Chen, X. PET of EGFR antibody distribution in head and neck squamous cell carcinoma models. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009, 50, 1116-23.
Chen, K. ; Xie, J. ; Xu, H. ; Behera, D. ; Michalski, M. H. ; Biswal, S. ; Wang, A. ; Chen, X. Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting. Biomaterials 2009, 30, 6912-9.
Xu, C. ; Xie, J. ; Ho, D. ; Wang, C. ; Kohler, N. ; Walsh, E. G. ; Morgan, J. R. ; Chin, E. Y. ; Sun, S. Au-Fe3O4 dumbbell nanoparticles as dual-functional probes. Angewandte Chemie (International ed. in English) 2008, 47, 173-6.
Wang, B. ; Xu, C. ; Xie, J. ; Yang, Z. ; Sun, S. pH controlled release of chromone from chromone-Fe3O4 nanoparticles. Journal of the American Chemical Society 2008, 130, 14436-7.
Xie, J. ; Chen, K. ; Lee, H. - Y. ; Xu, C. ; Hsu, A. R. ; Peng, S. ; Chen, X. ; Sun, S. Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells. Journal of the American Chemical Society 2008, 130, 7542-3.
Lee, H. - Y. ; Li, Z. ; Chen, K. ; Hsu, A. R. ; Xu, C. ; Xie, J. ; Sun, S. ; Chen, X. PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008, 49, 1371-9.
Peng, S. ; Wang, C. ; Xie, J. ; Sun, S. Synthesis and stabilization of monodisperse Fe nanoparticles. Journal of the American Chemical Society 2006, 128, 10676-7.