Research interests in the Analytical Chemistry division are representative of the great diversity of topics related to analytical chemistry.  Cutting-edge analytical techniques are used to characterize a wide variety of systems; from obtaining a fundamental understanding of the effect of nanoscale properties on the macroscopic behavior of electronic materials, to understanding the complex behavior of biological systems.  This involves a diverse array of analytical approaches, including scanning probe microscopy, mass spectrometry, optical spectroscopies, various methods for the characterization of electronic materials, and ultra-high vacuum based surface and thin-film analysis techniques.

Personnel

My research group specializes in the development and application of Fourier transform mass spectrometry for solving difficult problems in bioanalytical chemistry. We are exploring new methods for analyzing the structural features of glycosaminoglycans (GAGs), a class of carbohydrates that play a central role in a number of important biological…

The goal of our work is to understand how the chemical composition of aerosol particles influences their properties in the atmosphere and their effects on clouds and air quality. Our work focuses on characterizing the chemical composition and properties of surface-active organics (surfactants) in atmospheric aerosol particles. We look at the…

The research programs in our laboratory are centered on the investigation and development of novel materials and methods for the precise control of organic molecular assemblies, both in solution and on surfaces as ultrathin films.  Our research activities involve organic and polymer synthesis, surface sensitive characterization techniques, nano…

Our research focuses on the use of mass spectrometry to answer biological/biomedical questions. The majority of our projects involve characterizing the post-translational modifications (e.g., glycosylation, phosphorylation) present on the protein of interest. For example, we are currently investigating the in vivo changes that occur in human…

The advent of ultra high field magnets for NMR spectroscopy has opened important new avenues for understanding structure-function relationships in biological systems. Historically NMR has offered several advantages over other structural methods; it can be applied in a variety of environments, including aqueous solution and membrane phases; it…

Our research interests focus on the combination of analytical technologies (mass spectrometry, liquid chromatography, and ion mobility) with biological chemistry in order to address problems in protein and carbohydrate structure and function.  The majority of our projects revolve around the analysis of protein-reactive oxygen species products…

The Smith group studies the chemistry and optical properties of aerosol particles that are important in the atmosphere.  In particular, we develop instrumentation to measure how they scatter and absorb UV-visible sunlight.

We develop and use a variety of tools such as:

* photoacoustic spectroscopy (PAS) to measure absorption by…

Our group is interested in the study and growth of thin film materials. We are developing the electrochemical form of atomic layer epitaxy (ALE) or atomic layer deposition (ALD). ALE is a method where atomic layers of the elements making up a compound are deposited in a cycle, using surface limited reactions. In that way, growth is always layer…

Protein structure and function NMR spectroscopy of proteins and protein complexes Biophysical characterization of proteins Structural biology

The molecular details that define the structure, stability and function of interesting proteins and protein complexes, and those that dictate how proteins fold and interact with one another, are the focus…

Our research focuses on the development and evaluation of metal-, polymer- or protein-based nanoparticles for imaging and therapy. The idea is to conceptualize the nanoparticles not as merely tiny aggregates of molecules but rather as platforms with large surface-to-volume ratios. By harnessing the well-developed surface chemistry, one can load…