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Analytical Chemistry, Inorganic Chemistry, Biological Chemistry, Materials Chemistry and Nanoscience

Our research focuses on the development and evaluation of metal-, polymer- or protein-based nanoparticles applicable in an imaging and/or therapeutic context. The idea is to conceptualize the nanoparticles not as merely tiny aggregates of molecules but rather as platforms with large surface-to-volume ratios. By harnessing the well developed surface chemistry, one can load a wide range of functionalities onto the particle surface. We adopt an interdisciplinary approach, taking advantage of the recent progress made in peptide/protein/materials chemistry, bioconjugation, molecule imaging, cell/molecular biology as well as clinical medicine, and integrating these merits, with rational design, into nanoscale gadgets. The resulted products, with unique physical properties, targeting profiles, or theranostic attributes, are emerging as a new generation of therapeutic/imaging formula and hold great promise to improve patient management and treatment outcomes in a wide range of diseases, especially cancer.

 

Publications

Xie, J.; Liu, G.; Eden, H. S.; Ai, H.; Chen, X. Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. Acc. Chem. Res. 2011, 44(10), 883-92. Abstract
Xie, J.; Zhang, F.; Aronova, M.; Zhu, L.; Lin, X.; Quan, Q.; Liu, G.; Zhang, G.; Choi, K. - Y.; Kim, K.; Sun, X.; Lee, S.; Sun, S.; Leapman, R.; Chen, X. Manipulating the Power of an Additional Phase: A Flower-like Au-Fe(3)O(4) Optical Nanosensor for Imaging Protease Expressions In vivo. ACS nano 2011. Abstract
Zhu, L.; Xie, J.; Swierczewska, M.; Zhang, F.; Lin, X.; Fang, X.; Niu, G.; Lee, S.; Chen, X. Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions. Bioconjug. Chem. 2011, 22(6), 1001-5. Abstract
Lin, X.; Xie, J.; Niu, G.; Zhang, F.; Gao, H.; Yang, M.; Quan, Q.; Aronova, M. A.; Zhang, G.; Lee, S.; Leapman, R.; Chen, X. Chimeric ferritin nanocages for multiple function loading and multimodal imaging. Nano Lett. 2011, 11(2), 814-9. Abstract
Lin, X.; Xie, J.; Zhu, L.; Lee, S.; Niu, G.; Ma, Y.; Kim, K.; Chen, X. Hybrid ferritin nanoparticles as activatable probes for tumor imaging. Angew. Chem. Int. Ed. Engl. 2011, 50(7), 1569-72.
Liu, G.; Choi, K. Y.; Bhirde, A.; Swierczewska, M.; Yin, J.; Lee, S. W.; Park, J. H.; Hong, J. I.; Xie, J.; Niu, G.; Kiesewetter, D. O.; Lee, S.; Chen, X. Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)-Functionalized, Self-Assembled Nanoconjugate. Angewandte Chemie International Edition 2011, 51(2), 445-449.
Lee, S.; Xie, J.; Chen, X. Peptides and peptide hormones for molecular imaging and disease diagnosis. Chem. Rev. 2010, 110(5), 3087-111.
Huang, J.; Bu, L.; Xie, J.; Chen, K.; Cheng, Z.; Li, X.; Chen, X. Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles. ACS Nano 2010, 4(12), 7151-60. Abstract
Xie, J.; Lee, S.; Chen, X. Nanoparticle-based theranostic agents. Adv. Drug Deliv. Rev. 2010, 62(11), 1064-79. Abstract
Xie, J.; Chen, K.; Huang, J.; Lee, S.; Wang, J.; Gao, J.; Li, X.; Chen, X. PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 2010, 31(11), 3016-22. Abstract
Niu, G.; Li, Z.; Xie, J.; Le, Q. - T.; Chen, X. PET of EGFR antibody distribution in head and neck squamous cell carcinoma models. J. Nucl. Med. 2009, 50(7), 1116-23. Abstract
Chen, K.; Xie, J.; Xu, H.; Behera, D.; Michalski, M. H.; Biswal, S.; Wang, A.; Chen, X. Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting. Biomaterials 2009, 30(36), 6912-9. Abstract
Wang, B.; Xu, C.; Xie, J.; Yang, Z.; Sun, S. pH controlled release of chromone from chromone-Fe3O4 nanoparticles. J. Am. Chem. Soc. 2008, 130(44), 14436-7. Abstract
Xie, J.; Chen, K.; Lee, H. - Y.; Xu, C.; Hsu, A. R.; Peng, S.; Chen, X.; Sun, S. Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells. J. Am. Chem. Soc. 2008, 130(24), 7542-3. Abstract
Lee, H. - Y.; Li, Z.; Chen, K.; Hsu, A. R.; Xu, C.; Xie, J.; Sun, S.; Chen, X. PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J. Nucl. Med. 2008, 49(8), 1371-9. Abstract
Xu, C.; Xie, J.; Ho, D.; Wang, C.; Kohler, N.; Walsh, E. G.; Morgan, J. R.; Chin, E. Y.; Sun, S. Au-Fe3O4 dumbbell nanoparticles as dual-functional probes. Angew. Chem. Int. Ed. Engl. 2008, 47(1), 173-6.
Peng, S.; Wang, C.; Xie, J.; Sun, S. Synthesis and stabilization of monodisperse Fe nanoparticles. J. Am. Chem. Soc. 2006, 128(33), 10676-7. Abstract

Jin Xie

Assistant Professor

Postdoc National Institutes of Health 2009-2011

Postdoc Stanford University 2008-2009

Ph.D. Brown University 2004-2008

B.S. Nanjing University 1999-2003