Wei-Chih Lo Graduate Student, Department of Chemistry University of Georgia Learn more about the speaker Thursday, March 14, 2024 - 11:10am iSTEM Building 2, Room 1218 Organic Seminar Fischer carbene complexes with six valence electrons, characterized by a singlet carbene center, demonstrate an amphiphilic nature.1 The transition metal carbene complexes share similarities with Fischer carbene complexes, potentially functioning as both nucleophiles and electrophiles.2 This duality enables chemists to accomplish intricate transformations, such as C-H bond insertion or cyclopropanation. Despite their utility, the synthetic application of transition metal carbene complexes is often hindered by the preparation methods and stability of their carbene precursors, typically diazo compounds.3 Recent advancements have introduced methods to prepare non-stabilized carbene precursors, facilitating various reactions previously accessible through transition metal carbene complexes.4-6 References: [1] Nolan, S.P. Coord. Chem. Rev. 2009, 253, 862–892. [2] Doyle, M. P. Chem. Rev. 2010, 110, 704–724. [3] Bull, J. A. OPR&D 2020, 24, 67–84. [4] Nagib, D. A. Science 2022, 377, 649–654. [5] Nagib, D. A. Nat. Chem. 2024, 16, 107–113. [6] Nagib, D. A. Chem 2024, 10, 1–13. Research Areas: Organic Chemistry