Selected Publications

Mohammed, I. ; Hampton, S. E. ; Ashall, L. ; Hildebrandt, E. R. ; Kutlik, R. A. ; Manandhar, S. P. ; Floyd, B. J. ; Smith, H. E. ; Dozier, J. K. ; Distefano, M. D. ; Schmidt, W. K. ; Dore, T. M. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorganic & Medicinal Chemistry 2016, 24, 160 - 178.
McLain, D. E. ; Rea, A. C. ; Widegren, M. B. ; Dore, T. M. Photoactivatable, biologically-relevant phenols with sensitivity toward 2-photon excitation. Photochem. Photobiol. Sci. 2015, 14, 2151 - 2158.
Vandenberg, L. N. ; Blackiston, D. J. ; Rea, A. C. ; Dore, T. M. ; Levin, M. Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions. The International Journal of Developmental Biology 2014, 58, 799 - 809.
Rea, A. C. ; Vandenberg, L. N. ; Ball, R. E. ; Snouffer, A. A. ; Hudson, A. G. ; Zhu, Y. ; McLain, D.  E. ; Johnston, L. L. ; Lauderdale, J. D. ; Levin, M. ; Dore, T.  M. Light-Activated Serotonin for Exploring Its Action in Biological Systems. Chemistry & Biology 2013, 20, 1536 - 1546.
Ma, J. ; Rea, A. C. ; An, H. ; Ma, C. ; Guan, X. ; Li, M. - D. ; Su, T. ; Yeung, C. S. ; Harris, K. T. ; Zhu, Y. ; Nganga, J. L. ; Fedoryak, O. D. ; Dore, T. M. ; Phillips, D. L. Unraveling the Mechanism of the Photodeprotection Reaction of 8-Bromo- and 8-Chloro-7-hydroxyquinoline Caged Acetates. Chem.-Eur. J. 2012, 18, 6854-6865.
Abate-Pella, D. ; Zeliadt, N. A. ; Dore, T. M. ; Blank, D. A. ; Wattenberg, E. V. ; Distefano, M. D. Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation via One- and Two-Photon Excitation. ChemBioChem 2012, 13, 1009-1016.
Schmidt, W. K. ; Dore, T. M. The Ras Converting Enzyme (Rce1p): Orthologs, Enzymology, and Inhibitors. In The Enzymes; Tamanoi, F. ; Hrycyna, C. A. ; Bergo, M. ; The Enzymes; Elsevier/Academic Press: New York, 2011; Vol. 30B, pp. 231-258.
Ma, J. ; Cheng, S. C. ; An, H. ; Li, M. - D. ; Ma, C. ; Rea, A. C. ; Zhu, Y. ; Nganga, J. ; Dore, T. M. ; Phillips, D. L. Comparison of the Absorption, Emission, and Resonance Raman Spectra of 7-Hydroxyquinoline and 8-Bromo-7-Hydroxyquinoline Caged Acetate. J. Phys. Chem. A 2011, 115, 11632-11640.
Dore, T. M. ; Wilson, H. C. Chromophores for the Delivery of Bioactive Molecules with Two-Photon Excitation. In Photosensitive Molecules for Controlling Biological Function; Chambers, J. J. ; Kramer, R. H. ; Photosensitive Molecules for Controlling Biological Function; Humana Press: New York, 2011; pp. 57-92.
Dechert, A. - M. ; MacNamara, J. P. ; Breevoort, S. R. ; Hildebrandt, E. R. ; Hembree, N. W. ; Rea, A. C. ; McLain, D. E. ; Porter, S. B. ; Schmidt, W. K. ; Dore, T. M. Modulation of the Inhibitor Properties of (Acyloxy)methyl Ketones Toward the CaaX Proteases. Bioorganic & Medicinal Chemistry 2010, 18, 6230-6237.
An, H. - Y. ; Ma, C. ; Li, W. ; Harris, K. T. ; Dore, T. M. ; Phillips, D. L. Resonance Raman Characterization of the Different Forms of Ground-State 8-Substituted 7-Hydroxyquinoline Cage Acetate Compounds in Aqueous Solutions. Journal of Physical Chemistry A 2010, 114, 2498-2505.
Pirrung, M. C. ; Dore, T. M. ; Zhu, Y. ; Rana, V. S. Sensitized two-photon photochemical deprotection. Chemical Communications 2010, 46, 5313-5315.
An, H. - Y. ; Ma, C. ; Nganga, J. L. ; Zhu, Y. ; Dore, T. M. ; Phillips, D. L. Resonance Raman Characterization of Different Forms of Ground-State 8-Bromo-7-hydroxyquinoline Caged Acetate in Aqueous Solutions. Journal of Physical Chemistry A 2009, 113, 2831-2837.
Davis, J. M. ; Kragor, C. H. ; Reddie, K. G. ; Wilson, H. C. ; Zhu, Y. ; Dore, T. M. Substituent Effects on the Sensitivity of a Quinoline Photoremovable Protecting Group to One- and Two-Photon Excitation. Journal of Organic Chemistry 2009, 74, 1721-1729.
Porter, S. B. ; Hildebrandt, E. R. ; Breevoort, S. R. ; Mokry, D. Z. ; Dore, T. M. ; Schmidt, W. K. Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones. Biochimica et Biophysica Acta 2007, 1773, 853-862.
Zhu, Y. ; Pavlos, C. M. ; Toscano, J. P. ; Dore, T. M. 8-Bromo-7-hydroxyquinoline as a Photoremovable Protecting Group for Physiological Use: Mechanism and Scope. Journal of the American Chemical Society 2006, 128, 4267-4276.
Reddie, K. G. ; Roberts, D. R. ; Dore, T. M. Inhibition of kinesin motor proteins by adociasulfate-2. Journal of Medicinal Chemistry 2006, 49, 4857-4860.
Dore, T. M. Multiphoton Phototriggers for Exploring Cell Physiology. In Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules; Goeldner, M. ; Givens, R. S. ; Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules; Wiley-VCH: Weinheim, Germany, 2005; pp. 435-459.
Goard, M. ; Aakalu, G. ; Fedoryak, O. D. ; Quinonez, C. ; St. Julien, J. ; Poteet, S. J. ; Schuman, E. M. ; Dore, T. M. Light-Mediated Inhibition of Protein Synthesis. Chemistry & Biology 2005, 12, 685-693.
Lu, M. ; Fedoryak, O. D. ; Moister, B. R. ; Dore, T. M. Bhc-diol as a photolabile protecting group for aldehydes and ketones. Organic Letters 2003, 5, 2119-2122.