Current Research

My current research work focus on application of nanotechnology in biomedical engineering, particularly, my interests included but not limited to:

Circumvent Drug resistance in Cancer: Utilizing multifunctional nanoparticles as a delivery system that can bypass the biological barrier. Designing of small gold, silica nanoparticles, and polymer based nanoparticles system (micelles) for dual therapy, and low intersection peptide based delivery system for treatment of tumor microenvironment for potential cancer therapeutic application;

Nanotechnology for Neuroscience and Cardiovascular Disease: Design and development of brain-accumulating intracellular brain-targeted NPs with anti-oxidant and anti-inflammatory agents, to bypass the blood-brain barrier to treat Parkinson's, stroke, neonatal ischemia, multiple sclerosis and subarachnoid hemorrhage in animal models of these disorders, and development of nanotherapeutics for cardiovascular diseases and using polymer or metal based vehicles for delivering drug cargo to remove plaques;

Nanotechnology for Immunotherapy: Designed and development of technologies that use a combination of conventional cancer treatment and immunotherapy in a single nanoparticle platform to provide powerful tool to treat metastatic cancer;

Stimuli Responsive Delivery System : Designing and development of stimuli sensitive polymer and metals base hybrid nanoparticles platform with high payload and redox/thermal-responsive release behavior; minimizing the sizes of these nanoparticles to achieve passive targeting by enhanced permeability and  retention effect in tumor or engineering specific structures response to external stimulus such as pH and Near-Infrared light trigger release;

Organelles Targeted Drug Delivery Systems: Designed and development of cell/ organelle (mitochondria, nucleus, ER, Endothelial cells, Tumor fibroblast) targeted engineered nanoparticles that will offer several advantages over the existing drugs;.

Theranostic & Personalized Medicine for Better Healthcare: Engineering multifunctional biomedical nanoplatforms for imaging-guided cancer therapy; incorporating imaging (NIR-optical, photoacoustic, MRI, Ultrasound etc.) with traditional chemotherapy and novel cancer therapies (magnetic hyperthermia, photothermal, photodynamic and gene therapy etc.); exploring its potential for personalized medicine and better healthcare;

Nano-based Portable Devices for Rapid Detection: Functional-nanostructures-based adaptable sensors, such as fabricating nanoscale materials to build more sensitive, specific and adaptable sensors for early detection of infectious disease biomarkers, especially using the special optical, electronic and magnetic properties of nanomaterials; 

 

Publications:

  1. Ajay Chaudhary, Tariq Bhat, Sandeep Kumar, Anil Kumar, Rahul Kumar, Willie Underwood, Shahriar Koochekpour, Mojgan Shourideh, Neelu Yadav, Shanta Dhar, Dhyan Chandra“ Mitochondria dysfunction-mediated apoptosis resistance associates with defective heat shock protein response in African American prostate cancer’’ (2016), Br. J. Cancer, doi: 10.1038/bjc.2016.88  (In Press),
  2. Juan Liu, Tuo Wei, Jing Zhao, Yuanyu Huang, Hua Deng, Anil Kumar, Chenxuan Wang, Zicai Liang, Xiaowei Maa, Xing-Jie Liang, “Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance’’(2016), Biomaterials, 91, 44–56
  3. Ru Wen, Bhabatosh Banik, Rakesh K. Pathak, Anil Kumar, Nagesh Kolishetti, Shanta Dhar “Nanotechnology inspired tools for mitochondrial dysfunction related diseases’(2016), Adv. Drug Deliv. Rev,  99, 52–69
  4. Akil Kalathil*, Anil Kumar*, Bhabatosh Banik, Timothy A. Ruiter, Rakesh K. Pathak, Shanta Dhar “New formulation of old aspirin for better delivery’’(2016), Chem. Commun, , 52, 140-143 (* co-first author)
  5. Chen Fei, Zhao Yuanyuan, Pan Yuanming, Xue Xiangdong, Zhang Xu, Anil Kumar, Xing-Jie Liang “Synergistically Enhanced Therapeutic Effect of HCPT/DOX on Breast Cancer Cells through Improved Cellular Accumulation of Dual drug Nanoparticles’’ (2015), Mol. Pharmaceutics, 12,  2237–2244
  6. Xiangdong Xue,Yuanyuan Zhao, Xu Zhang, Chunqiu Zhang, Anil Kumar, Xiaoning Zhang, Guozhang Zou, Paul C. Wang, Jinchao Zhang, Xing-Jie Liang “Phenylboronic Acid Functionalized Magnetic Nanoparticles for One-step Saccharides Enrichment and Mass Spectrometry’’ (2015), Analysis Biophysics Report, 1, 61-70 , Cover Page Articles
  7. Jianhua Li, Xiaoning Mou, Jichuan Qiu, Shu Wang, Dongzhou Wang, Dehui Sun, Weibo Guo, Deshuai Li, Anil Kumar, Xuebin Yang, Aixue Li, Hong Liu “Surface Charge Regulation of Osteogenic Differentiation of Mesenchymal Stem Cell on Polarized Ferroelectric Crystal Substrate’’ (2015), Advanced Healthcare Materials, 4,998–1003
  8. Jian Tian, Zhenhuan Zhao, Anil Kumar, Hong Liu, “Recent progress in design, synthesis, and applications of one-dimensional TiO2 nanostructured surface heterostructures: a review’’ (2014), Chemical Society Reviews, 43, 6920-37
  9. Xu Zhang, Yuanyuan Zhao, Yi Xu, Fei Chen, Yonggang Jiang, Anil Kumar, Guozhang Zou, Xing Jie Liang “'In situ self-assembly of peptides in glucan particles for macrophage-targeted oral delivery’’ (2014) , Journal of Materials Chemistry B, 2, 5882-5890.
  10. Anil Kumar, Shuaidong Huo, Xu Zhang, Juan Liu, Aaron Tan, Shengliang Li, Shubin Jin, Xiangdong Xue, YuanYuan Zhao, Hong Liu, XiaoNing Zhang, Jinchao Zhang, Guozhang Zou, Tianyou Wang, Suoqin Tang, and Xing Jie Liang; “Neuropilin-1-Targeted Gold Nanoparticles Enhance Therapeutic Efficacy of Platinum(IV) Drug for Prostate Cancer Treatment’(2014), ACS Nano, 8, 4205–4220
  11. Shengliang Li, Weipeng Cao, Anil Kumar, Shubin Jin, Yuanyuan Zhao, Chunqiu Zhang, Guozhang Zou, Paul C. Wang, Feng Li, XingJie Liang; “Highly sensitive simultaneous detection of mercury and copper ions by ultrasmall fluorescent DNA–Ag nanoclusters’’(2014), New Journal of Chemistry, 38, 1546-1550
  12. Shuaidong Huo, Shubin Jin, Ma Xiaowei, Xiangdong Xue, Keni Yang, Anil Kumar, Paul C Wang, Jinchao Zhang, Zhongbo Hu, Xing Jie Liang; “Ultra-Small Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry’’ (2014), ACS Nano, 8, 5852–5862
  13. Dong Zhou Wang, Bo Xia Yan, Yong Bi, De Hui Sun, Yuan Hua Sang, Hong Liu,  Anil Kumar, Robert I. Boughton,“ Three- wavelength green laser using intracavity frequency conversion of Nd:Mg:LiTaO 3 with a MgO:PPLN crystal’’ (2014),  Applied Physics B,117, 1117-11121
  14. Juan Liu, Yuran Huang, Anil  Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing Jie Liang; “pH-Sensitive nano-systems for drug delivery in cancer therapy” (2013), Biotechnology Advances, 32, 693-710
  15. Anil Kumar, Fei Chen, Anbu Mozhi, Xu Zhang, Yuanyuan Zhao, Xiangdong Xue, Yanli Hao, Xiaoning Zhang, Paul C. Wang, Xing Jie Liang; “Innovative Pharmaceutical Development Based on Unique Properties of Nanoscale Delivery Formulation” (2013), Nanoscale, 5, 8307–8325
  16. Anil Kumar, Xu Zhang, Xing Jie Liang; “Gold Nanoparticles: Emerging Paradigm for Targeted Drug Delivery System’’ (2013),  Biotechnology Advances, 31, 593-606
  17. Xiangdong Xue, Yuanyuan Zhao, Luru Dai, Xu Zhang, Xiaohong Hao, Chunqiu Zhang, Shuaidong Huo, Juan Liu, Chang Liu, Anil Kumar, Wei-Qiang Chen, Guozhang Zou, Xing Jie Liang; “Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation-Induced Emission” (2013),  Advance Materials, 26, 712-717
  18. Yuanyuan Zhao, Xu Zhang, Xiangdong Xue, Zhipeng Li, Fei Chen, Shengliang Li, Anil Kumar, Guozhang Zou, Xing Jie Liang; “High Throughput Detection of Human Neutrophil Peptides from Serum, Saliva and Tear by Anthrax Lethal Factor-Modified Nanoparticles” (2013), ACS Applied Materials and Interfaces, 5, 8267-8272
  19. Anil Kumar, Huili Maa, Xu Zhang Keyang Huang, Shubin Jin, Juan Liu, Tuo Wei, Weipeng Cao, Guozhang Zou, Xing Jie Liang; “Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment” (2012),  Biomaterials, 33, 1180-89
  20. Keyang Huang, Huili Ma, Juan Liu, Shuaidong Huo, Anil Kumar, Tuo Wei, Xu Zhang, Shubin Jin, Yaling Gan, Paul C. Wang, Shengtai He, Xiaoning Zhang, and Xing Jie Liang; “Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo” (2012),  ACS Nano, 6, 4483-4493
  21. Hua Deng, Xu Zhang, Anil Kumar, Guozang Zou, Xiaoning Zhang and Xing Jie Liang; Long genomic DNA amplicons adsorption onto unmodified gold nanoparticles for colorimetric detection of Bacillus anthracis” (2012), Chem Commun, 49, 51-53
  22. Lu Han, Li-Bo Du, Anil Kumar, Hong-Ying Jia, Liang Xing jie, Qiu Tian and Yang Liu; “Inhibitory effects of trolox-encapsulated chitosan nanoparticles on tert-butylhydroperoxide induced RAW264.7 apoptosis” (2012), Biomaterials, 33, 8517-8528
  23. Xing Jie Liang, Anil Kumar, Donglu Shi, and Daxiang Cui; “Nanostructures for Medicine and Pharmaceuticals” (2012), Journal of Nanomaterials, (Editorial), Article ID 921897, 2 pages, 2012. doi:10.1155/2012/921897
  24. Anil Kumar, Bhargavi M. Boruah, Xing Jie Liang; “Gold Nanoparticles: Promising Nanomaterials for the Diagnosis of Cancer and HIV/AIDS” (2011), Journal of Nanomaterials, Article ID 202187, 17 pages doi:10.1155/2011/202187
  25. Shutao Guo, Yuanyu Huang, Tuo Wei, Wendi Zhang, Weiwei Wang, Daoshu Lin, Xu Zhang, Anil Kumar, Quan Du, Jinfeng Xing, Liandong Deng, Zicai Liang, Paul C. Wang, Anjie Dong, Xing Jie Liang; “Amphiphilic and biodegradable methoxy polyethylene glycol-block (polycaprolactone-graft-poly(2 (dimethylamino) ethyl methacrylate)) as an effective gene carrier” (2011), Biomaterials, 32, 879-88

Book Chapters:

  1. Anil Kumar, Bhargavi M. Boruah, Xing Jie Liang “Gold complex as prospective metal based anticancer drug” (2013) Encyclopedia of Metalloproteins edited by (Kretsinger, Robert H.; Permyakov, Eugene A.; Uversky, Vladimir N) Springer Science Publication 233 Spring Street, New York, NY 10013-1578, ISBN 13: 9781461415336, ISBN 10: 1461415330
  2. Anil Kumar, Xing Jie Liang “Gold nanomaterials as prospective metal based delivery system for cancer treatment” (2012) Encyclopedia of Metalloproteins edited by (Kretsinger, Robert H.; Permyakov, Eugene A.; Uversky, Vladimir N) Springer Science Publication 233 Spring Street, New York, NY 10013-1578, ISBN 13: 9781461415336, ISBN 10: 1461415330
  3. Anil Kumar, Bhargavi M. Boruah, Xing Jie Liang, “Interaction of nanoparticles with the immune system and their significance in drug-design and development” (2011), Nanopharmaceuticals: The Pharmaceutical Application of Nanotechnology (Xing-jie, Liang Ed.), World Scientific Publishing Co., Inc. ISBN: 978-981-4368-66-7