Skip to main content
Skip to main menu Skip to spotlight region Skip to secondary region Skip to UGA region Skip to Tertiary region Skip to Quaternary region Skip to unit footer

Slideshow

Decarboxylative Fluoroalkylation and Fluorination Strategies for Modulating Properties of Neurotherapeutics

Ryan Alan Altman
University of Kansas Medicinal Chemistry
Chemistry Building, Room 400
Organic Seminar

Alcohols, ketones and aldehydes represent some of the most commonly exploited functional groups for synthetic transformations, and the extensive number of these motifs in natural products and pharmaceutically important building blocks provides a wide variety of potential substrates for transformations. In this field, we have developed new reactions and synthetic sequences using decarboxylative strategies and fluorinated alkenes to convert simple O-based functional groups into biomedically significant fluorinated substructures, and confirmed that these methods streamline the syntheses of target molecules. These methods enable synthetic chemists to efficiently access new fluorinated target molecules with physicochemical and biophysical properties that align with drug-like characteristics. Additional ongoing work aims to employ fluorinated peptidomimetics and ethermimetics to perturb physicochemical and biophysical properties of neurotherapeutics.

Support Us

We appreciate your financial support. Your gift is important to us and helps support critical opportunities for students and faculty alike, including lectures, travel support, and any number of educational events that augment the classroom experience. Click here to learn more about giving.

Every dollar given has a direct impact upon our students and faculty.

Got More Questions?

Undergraduate inquiries: chemreg@uga.edu 

Registration and credit transferschemreg@uga.edu

AP Credit, Section Changes, Overrides, Prerequisiteschemreg@uga.edu

Graduate inquiries: chemgrad@uga.edu

Contact Us!

Assistant to the Department Head: Donna Spotts, 706-542-1919 

Main office phone: 706-542-1919 

Main Email: chem-web@franklin.uga.edu

Head of Chemistry: Prof. Jason Locklin