Platinum (IV) complexes for use in dual mode pharmaceutical therapy
. Application: WOWO: (Massachusetts Institute of Technology, USA).; 2010.
The present invention provides compns., prepns., formulations, kits, and methods useful for treating subjects in need of therapeutic protocol, including subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a compn. comprising a first component comprising a precursor to a therapeutically active platinum agent and a precursor to a second therapeutically active agent. The therapeutically active platinum agent and the second therapeutically active agent may dissoc. from each other, thereby forming a first therapeutically active platinum agent and a second therapeutically active agent. The second therapeutically active gent may affect a cellular pathway of a cancer cell and may be substantially inactive towards non-cancerous cells. [on SciFinder(R)]