Department of Chemistry

Dhar, S.; Reddy, P. A. N.; Chakravarty, A. R. Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(II) complex. Dalton Transactions 2004, 697-698.

Abstract

The axial aqua bound copper(II) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase expts., with a rate of 5.58±0.4 h-1 and a rate enhancement of 1.55 × 108. [on SciFinder(R)]