High density orthogonal surface immobilization via photoactivated copper-free click chemistry.
Surfaces contg. reactive ester polymer brushes were functionalized with cyclopropenone-masked dibenzocyclooctynes for the light activated immobilization of azides using catalyst-free click chem. The photodecarbonylation reaction in the amorphous brush layer is first order for the first 45 s with a rate const. of 0.022 s-1. The catalyst-free cycloaddn. of surface bound dibeznocyclooctynes proceeds rapidly in the presence of azides under ambient conditions. Photolithog. using a shadow mask was used to demonstrate patterning with multiple azide contg. mols. This surface immobilization strategy provides a general and facile platform for the generation of multicomponent surfaces with spatially resolved chem. functionality. [on SciFinder(R)]