Chemistry Faculty:
Todd C. Harrop, Ph.D.
Assistant Professor
Phone: 706-542-3486
E-mail: tharrop@chem.uga.edu
Biographical Information
B.S., Saint Mary's College of California, 1998
Ph.D., University of California, Santa Cruz, 2004
NIH Postdoctoral Fellow, Massachusetts Institute of Technology, 2005-2007
Research Interests
The research in the Harrop group focuses on aspects in the area of bioinorganic chemistry. These interests include the rational design and synthesis of structural and functional models of metalloenzyme active sites involved in small molecule activation, especially the superoxide detoxifying enzymes like superoxide reductase (SOR, a non-heme iron enzyme) and the nickel containing superoxide dismutase (Ni-SOD). The goal is to design and develop synthetic routes for ligand sets that structurally mimic the spatial disposition and donor strength (imidazole-N and cysteine-S) observed at the active site of these enzymes. We intend to perform and understand the reactivity of the model systems with superoxide and other ROS species in order to gain insight on the mechanism of superoxide detoxification. Additionally, the lab aims to systematically construct organic molecules with applications in environmental remediation and sensing of toxic heavy metal ions like arsenic (As3+) and lead (Pb2+). The aim of this project is to construct ligand frames utilizing metal specific donor groups that will form supramolecular coordination complexes with these particular toxic ions. Synthetic tweeking of the receptor molecules with fluorescent reporter groups will then allow us to detect the presence of these ions in an aqueous environment. Collectively, the proposed research fuses together many areas of chemistry providing multidisciplinary projects that should be of broad interest to students from diverse backgrounds.
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Publications
Harrop, Todd C.; Song, Datong; Lippard, Stephen J., Reactivity Pathways for Nitric Oxide and Nitrosonium with Iron Complexes in Biologically Relevant Sulfur Coordination Spheres, J. Inorg. Biochem., 2007, in press.
Conradie, Jeanet; Quarless, Duncan A., Jr.; Hsu, Hua-Fen; Harrop, Todd C.; Lippard, Stephen J.; Koch, Stephen A.; Ghosh, Abhik, Electronic Structure and FeNO Conformation of Nonheme Iron-Thiolate-NO Complexes: A Combined Experimental and DFT Study, J. Am. Chem. Soc., 2007, in press.
Harrop, Todd C.; Song, Datong; Lippard, Stephen J., Interaction of Nitric Oxide with Tetrathiolato Iron(II) Complexes: Relevance to the Reaction Pathways of Iron Nitrosyls in Sulfur-Rich Biological Coordination Environments, J. Am. Chem. Soc., 2006, 128, 3528-3529.
Harrop, Todd C.; Mascharak, Pradip K., Model Complexes of Ni-Containing Enzymes. In Concepts and Models in Bioinorganic Chemistry; Kraatz, H.-B., Metzler-Nolte, N., Eds.; Wiley & Sons: New York, 2006; Chapter 14.
Harrop,
Todd C.; Olmstead, Marilyn M.; Mascharak, Pradip K., Synthetic
Analogues of the Active Site of the A-Cluster of Acetyl Coenzyme A
Synthase/CO Dehydrogenase: Syntheses, Structures, and Reactions with
CO, Inorg. Chem., 2006, 45, 3424-3436.
Harrop, Todd C.; Olmstead, Marilyn M.; Mascharak, Pradip K., Modeling the Active Site of Nitrile Hydratase: Synthetic Strategies to Ensure Simultaneous Coordination of Carboxamido-N and Thiolato-S to Fe(III) Centers, Inorg. Chem., 2005, 44, 9527-9533.
Harrop, Todd C.; Olmstead, Marilyn M.; Mascharak, Pradip K., Unusual Role of Solvents in the Syntheses of {Fe-NO}6/7 Nitrosyls Derived from a Ligand with Carboxamido Nitrogen and Thiolato Sulfur Donors, Inorg. Chem., 2005, 44, 6918-6920.
Harrop,
Todd C.; Mascharak, Pradip K., Structural and Spectroscopic Models of
the A-Cluster of Acetyl Coenzyme A Synthase/Carbon Monoxide
Dehydrogenase: Nature’s Monsanto Acetic Acid Catalyst, Coord. Chem. Rev., 2005, 249, 3007-3024.
Harrop,
Todd C.; Olmstead, Marilyn M.; Mascharak, Pradip K., Structural Models
of the Bimetallic Subunit at the A-Cluster of Acetyl Coenzyme A
Synthase/CO Dehydrogenase: Binuclear Sulfur-Bridged Ni-Cu and Ni-Ni
Complexes and Their Reactions with CO, J. Am. Chem. Soc., 2004, 126, 14714-14715.
Harrop,
Todd C.; Mascharak, Pradip K., Roles of Carboxamido Nitrogen and
Modified Cysteine Sulfur in Metalloenzymes: Lessons Learned from
Nitrile Hydratase (NHase), Acc. Chem. Res., 2004, 37, 253-260.