Chemistry Faculty:
Bi-Cheng Wang, Ph.D.
Professor
Ramsey-GRA Eminent Scholar in Structural Biology
Phone: 706-542-1747
E-mail: wang@bcl1.biochem.uga.edu
Biographical Information
Ph.D., University of Arkansas, 1968
Postdoctoral Fellow, California Institute of Technology, 1968-70
Research Interests
After postdoctoral training at the California Institute of Technology and the University of Pittsburgh, Dr. Wang joined the University of Pittsburgh where he rose through the ranks to become a professor in the Departments of Crystallography and Biological Sciences before coming to Georgia in 1995. He has served on the Biophysical Chemistry Study Section for NIH, as President of the Pittsburgh Diffraction Society and Co-editor of Crystallographic Reviews. His research interests are in the structure and function of a wide range of important biological macromolecules including RNA polymerases and their DNA and DNA-RNA complexes, neurophysins and their hormone complexes, glutathione transferases and mutants, aldehyde dehydrogenase and mutants, hyperthermophilic bacterium alcohol dehydrogenase, augmenter of liver regeneration, feedback regulator proteins, ferrochelatase, surface proteins of avian virus, mutant proteins of hemerythrin and myohemerythrin, archaeal transcription pre-initiation complexes, glutamine binding protein and its glutamine complex, and plant cell wall polysaccharides. He has also been involved in developing new techniques for the determination of macromolecular structures. Dr. Wang's research is supported by NIH.
Publications
B.C. Wang. "Resolution of Phase Ambiguity in Macromolecular Crystallography," in Diffraction Methods for Biological Macromolecules, Vol. B115 of Methods in Enzymology, Academic Press, 1985, pp. 90-112.
L. Chen, J.P. Rose, E. Breslow, D. Yang, W.R. Chang, C.S. Yoo, W.F. Furey, Jr., M Sax and B.C. Wang. "Crystal Structure of a Bovine Neurophysin II Dipeptide Complex at 2.8? A Determined from the Use of the Single-Wavelength Anomalous Scattering Signal of an Incorporated Iodine Atom," Proc. Natl. Acad. Sci. USA, 88, 4240-4244 (1991).
R. Sousa, Y.J. Chung, J.P. Rose, and B.C. Wang. "Crystal Structure of Bacteriophage T7 RNA Polymerase at 3.3l A Resolution," Nature, 364, 593-599 (1993).
B.C. Wang, J.P. Rose, G. Arents and E.N. Moudrianakis. "The Octameric Histone Core of Nucleosome: The Structural Issues Resolved," J. Mol. Biol. 236, 179-188 (1994).
J.P. Rose, C.K. Wu, C.H. Hsaio, E. Breslow and B.C. Wang. "Crystal Structure of the Neurophysin-Oxytocin Complex," Nature Structural Biology, 3, 163-169 (1996).
C.D. Hsiao, Y.J. Sun, J.P. Rose and B.C. Wang. "The Crystal Structure of Glutamine-Binding Protein from Escherichia coli," J. Mol. Biol. 262, 225-242 (1996).
Z.J. Liu, J. Sun, J. Rose, Y.J. Chung, C.D. Hsiao, W.R. Chang, I. Kuo, J. Perozich, R. Lindahl, J. Hempel and B.C. Wang. "The First Structure of an Aldehyde Dehydrogenase Reveals Novel NAD-Binding Interactions with Rosemann Fold," Nature Structural Biology, 4, 317-326 (1997).